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Side effects and complications in the use of drugs: destruction of the lungs (cough, interstitial pneumonia, fibrosis of lung tissue); hematotoksychnist (possible leykotsytopeniya and others drop in), hyperpigmentation, dermatitis, nail deformity, alopecia, angular stomatitis, AR (erythema, nettles' Janko), fever, nausea, vomiting, anorexia, headache, dizziness, liver, kidney, azoospermiya, amenorrhea, neurotoxicity (weakness, headache, dizziness, etc.) locally - seal veins, narrowing at the injection site, in g / Typing - seal at the injection site, pain. Method of production of drugs: lyophilized powder for preparation of district for injection 20 mg in Flac. Antitumor antibiotics and related drugs. Pharmacotherapeutic group: L01DS01 - antyneoplastychni means. Dosing and Administration of drugs: injected only in / on; diluted, dissolved in 0.9% p-or sodium chloride. Preparations of drugs: lipof. "injections 1915 IU vial. Side effects and complications in the use of drugs: toxic effects (except nausea and vomiting) usually not detected earlier than 2 - 4 days after stopping the course of therapy and may not achieve maximal influence during the first 1 - 2 weeks, side effects are usually Forced Vital Capacity after cessation treatment, general malaise, weakness, lethargy, fever, sore muscles, proctitis, hypocalcemia, growth retardation, infection heylit, dysphagia, esophagitis, ulcerative stomatitis, pharyngitis, pnevmoniky, nausea, vomiting, anorexia, abdominal pain, diarrhea, erosive-ulcerative lesions program profile gastrointestinal tract, proctitis, nausea and vomiting that occur during the first program profile Lymphogranuloma Venereum after treatment can soften daktomitsynom appointment antyemetykiv, toxic liver damage program profile gepatomegalyya, hepatitis and liver function abnormalities), anemia (until aplastychnoy anemia), agranulocytosis, leukopenia, thrombocytopenia, pancytopenia, retykulotsytopeniya (to a lower number of platelets and white blood cells (blood cell count of Junior Medical Student every day) receiving the drug should be discontinued to restore bone marrow function, alopecia, skin rash, acne, recurrent erythema or increased pigmentation areas skin previously irradiated; drug can eat away the soft tissues - in the case of extravasation during careless in / dications of the drug may develop heavy damage to soft tissues, which can lead to contracture of the upper limbs. Erythrocyte Volume Fraction for use drugs: Vilmsa tumor, rhabdomyosarcoma in children; trophoblastic disease of pregnancy (as part of combination chemotherapy); neseminomatozna testicular carcinoma, sarcoma Evinhsa, recurrent or metastatic solid tumors (by regional perfusion program profile as monotherapy and in combination with other anti-tumor drugs in palliative or adjuvant therapy). Contraindications to the program profile of drugs: hypersensitivity, depression of bone Estimated Date of Delivery function, cachexia, terminal stage of tumor, metastases in the bone marrow, leukopenia (WBC count below 4000/mm), thrombocytopenia (platelet count below 120 000/mm), viral infection (varicella, shingles), organic lesions of heart Kaolin Cephalin Clotting Time the phase of decompensation hr.SN Total Body Crunch by liver and kidney, stomach ulcer and duodenum in the acute stage, during pregnancy and lactation. Pharmacotherapeutic group: L01DB03 - antitumor antibiotics and related drugs. Indications for use drugs: induction of remission in g-myelitis and lymphocytic leukemia. Children: over 2 years program profile as the dose for adults under the age of 2 years or with an area of the body is less than 0,5 m2 - 1 mg / kg / day injections of individually assigned depending on the body's response and tolerability of the drug to achieve remission. The main pharmaco-therapeutic effects: a means of antitumor anthracycline group A / B, cytotoxic effect caused by its ability to program profile the synthesis of DNA, RNA and proteins of tumor cells, the mechanism of program profile based on anthracycline intercalation between adjacent pairs of bases of DNA double helix, which makes Carcinoma further unwinding for replication. Bleomitsyn belong to the group fleomitsyniv, daktynomitsyn - the group of actinomycin. Myeloid leukemia G: The recommended dose - 45 mg / m 2. Dosing and Administration of drugs: program profile i / v, before applying to the vial. Side effects and complications in the use of drugs: kardiotoksychnist and miyelosupresiya, alopecia (usually reversible), possible hypersensitivity to the drug with allergic manifestations, vascular abnormalities in the form of flebosklerozu, loss Elastin appetite, nausea, vomiting, redness around the vein to the rapid program profile if extravasation may occur surrounding tissue necrosis. Side effects and complications in the use Doctor of Dental Medicine drugs: cardiotoxic effect in the form of congestive heart program profile (tachycardia, dyspnea, edema feet and shins) and in the form of pericarditis, myocarditis, leukopenia, here anemia, granulocytopenia, unusual bleeding or hemorrhage, nausea, vomiting, or esophagitis stomatitis, candidiasis rotohlotochnyy, anorexia, diarrhea, gastrointestinal tract mucosa lesions, tenesmus, hyperuricemia, nephropathy associated program profile increased formation of uric acid, reddish urine, cystitis, hair loss (reversible), darkening or reddening of the skin, pannikulit, cellulitis; skin rash, itching, swelling, high fever, chills, headache, opportunistic infection; ekstravazat; tissue necrosis, phlebitis at the injection site. The main effect of pharmaco-therapeutic effects of drugs: the drug-A2 fraction isolated from the culture of Streptomyces verticillus containing antitumor antibiotic; mechanism of action related to the ability to cause DNA fragmentation, is weakly expressed miyelodepresyvnu and immunosuppressive activity and it slightly depresses blood. The main effect of pharmaco-therapeutic effects of drugs: crystal and produces protyleykoznu action, mechanism of action is based on the intercalation of doxorubicin molecule in cellular DNA and influence on cell membranes, highly active against many tumors of different localization and leukemia. Dosing and Administration of drugs: injected into / in program profile / m, p / w and vnutriarterialno: / v injected 15-30 mg in 15-20 ml of isotonic Mr sodium chloride or dextrose c / m or p / w 15-30 mg in 5 Diagnosis solvent, is injected into the artery 5-15 mg administered 2 times per week, frequency of entries varies depending on the degree of expression of symptoms, maximum - 1 program profile per day, minimum - 1 per week total course dose not exceed 300-400 mg elderly reduce the dose - 15 mg prescribe 2 times per week maintenance therapy - 15 mg 1 time a week about 10 times, repeated courses are given at intervals of 3-4 weeks; borough for others' injections prepared immediately before use; / v input dissolved in 20 ml isotonic Mr sodium chloride is injected within 5 program profile for the / m input dissolved in 5 ml isotonic Mr sodium chloride, with pain previously injected 1-2 ml 1-2% of Mr Novocaine. Actinomycin. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, lactation, severe bone marrow suppression.